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2 edition of Human plasma glutathione peroxidase as a risk factor for ischaemic heart disease. found in the catalog.

Human plasma glutathione peroxidase as a risk factor for ischaemic heart disease.

Marilyn Porter

Human plasma glutathione peroxidase as a risk factor for ischaemic heart disease.

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Published by University of Manchester in Manchester .
Written in English


Edition Notes

ContributionsUniversity of Manchester. Faculty of Medicine.
The Physical Object
Pagination254p.
Number of Pages254
ID Numbers
Open LibraryOL16427903M

Increased oxidative stress from both mitochondrial and cytosolic sources contributes to the development and the progression of cardiovascular diseases (CVDs), and it is a target of therapeutic interventions. The numerous efforts made over the last decades in order to develop tools able to monitor the oxidative stress level in patients affected by CVDs rely on the need to gain information on Lycopene is also widely distributed in the human body. It is one of the major carotenoids found in the human serum (between 21 and 43% of total carotenoids) with plasma levels ranging from to nmol/ml (Cohen, ).It is also found in various tissues throughout the body such as the liver, kidney, adrenal glands, tests, ovaries and the prostate gland (Basu & Imrhan, ). /the-anti-atherogenic-effects-of-lycopene.   disease (CAD), with a median followup period of years (maximum, ), suggested that increasing glutathione-1 peroxidase activity might lower the risk of cardiovascular events [24]. A thorough review on the relations between plasma glutathione levels and CVD suggested that reduced plasma total glutathione levels are a risk factor for Glutathione peroxidase. Glutathione peroxidase (GPx) is an enzyme that is responsible for protecting cells from damage due to free radicals like hydrogen and lipid peroxides. The GPx (EC ) contains a single selenocysteine selenocysteine (Sec) residue in each of the four identical subunits, which is essential for enzyme activity. GPX

  SOD), plasma glutathione peroxidase (GPx-3), erythrocyte glutathione peroxidase (GPx-1) and erythrocyte glutathione Age is a main risk factor in case of the most commonly reported two prostate problems: be - nign prostate hyperplasia (BPH) and prostate adenocarcinoma (PC) [1, 2, 3]. BPH affects 20% of men in age of 40 and 70% of


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Human plasma glutathione peroxidase as a risk factor for ischaemic heart disease. by Marilyn Porter Download PDF EPUB FB2

Plasma glutathione peroxidase (GPx-3) is a major antioxidant enzyme in plasma and, as a member of the selenocysteine-containing GPx family, scavenges hydrogen peroxide and organic (lipid) hydroperoxides produced during normal metabolism or after oxidative insult. 7, 8 Of the five known GPx isoforms, GPx-3 is the only one found in the Plasma, platelet and erythrocyte glutathione peroxidases as risk factors in ischaemic heart disease in man.

Clin Sci (Lond). ; – Crossref Medline Google Scholar; 17 Muzakova V, Kandar R, Vojtisek P, Skalicky J, Cervinkova Z. Selective antioxidant enzymes during ischemia/reperfusion in myocardial infarction. Physiol ://   Glutathione peroxidase-3 (GPx-3) is a selenocysteine-containing plasma protein that scavenges reactive oxygen species in the extracellular compartment.

A deficiency of this enzyme has been associated with platelet-dependent thrombosis, and a promoter haplotype with reduced function has been associated with stroke risk in young ://   Selenium as a Risk Factor for Cardiovascular Diseases Show all authors.

Jean Nève, Dr Purification and characterization of human plasma glutathione peroxidase: A selenoprotein distinct from the known cellular enzyme Serum selenium concentration and risk of Ischaemic heart disease in a prospective cohort study of males Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, et al.

Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children. Stroke.

; – [PMC free article] In a cross-sectional population study of unselected Eastern Finnish men aged 54 years, serum selenium concentration had a weak positive associati   The protein encoded by this gene belongs to the glutathione peroxidase family, members of which catalyze the reduction of organic hydroperoxides and hydrogen peroxide (H2O2) by glutathione, and thereby protect cells against oxidative damage.

Several isozymes of this gene family exist in vertebrates, which vary in cellular location and substrate :// Glutathione 2 is active mainly in the intestine, whereas glutathione peroxidase 3 is active mainly in plasma. Glutathione peroxidase activity is dependent on the mineral selenium, which bonds to the enzyme and gives it shape and form.

Without selenium glutathione peroxidase cannot Health benefits of selenium boil down to its crucial antioxidant role as part of the enzyme glutathione peroxidase (GPx). Glutathione peroxidases, also known as selenoproteins, are a family of antioxidant enzymes that speed up the reaction between glutathione and free radicals, particularly toxic hydrogen peroxide, which selenium-containing glutathione peroxidases help transform to harmless The a priori selected endpoint was coronary heart disease, which was defined as any combination of fatal or nonfatal coronary heart disease and myocardial infarction.

Studies reporting only total cardiovascular endpoints were also included, because coronary heart disease is the major contributor to cardiovascular disease in many :// Voetsch B, Jin R, Bierl C, Deus-Silva L, Camargo E, Annichino-Bizacchi J, Handy D and Loscalzo J () Role of Promoter Polymorphisms in the Plasma Glutathione Peroxidase (GPx-3) Gene as a Risk Factor for Cerebral Venous Thrombosis, Stroke,(), Online publication date: 1-Feb However, the LDL to HDL cholesterol ratio does not take into account other blood lipids, that may also be a risk factor for cardiovascular disease.

Recent studies have found that the plasma levels of apolipoprotein (apo) B, and more specifically the ratio of apo B to apo A-1, may be a more accurate predictor of cardiovascular Physiologic concentrations of homocysteine inhibit the human plasma GSH peroxidase that reduces organic hydroperoxides K Takahashi, N Avissar, J Whitin, H CohenPurification and characterization of human plasma glutathione peroxidase: a platelet and erythrocyte glutathione peroxidases as risk factors in ischaemic heart disease in :// Nonetheless, multiple studies demonstrate a major genetic component to the risk for arterial thrombotic/ischemic heart disease.

For example, a recent twin study estimated a heritability of ~50% for mortality from coronary heart disease. 6 Thousands of clinical studies have repeatedly assessed hundreds of potential candidate genetic risk factors with generally confusing and contradictory :// ///Genetic-Risk-Factors-for-Arterial-Thrombosis-and.

Bierl C. et al. Determinants of human plasma glutathione peroxidase (GPx-3) expression. J Biol Chem ; Voetsch B. et al. Promoter polymorphisms in the plasma glutathione perox-idase (GPx-3) gene: a novel risk factor for arterial ischaemic stroke among young adults and children.

Stroke ;   Shuman Yang, Majken K. Jensen, Eric B. Rimm, Walter Willett, Tianying Wu, Erythrocyte Superoxide Dismutase, Glutathione Peroxidase, and Catalase Activities and Risk of Coronary Heart Disease in Generally Healthy Women: A Prospective Study, American Journal of Epidemiology, VolumeIssue 9, 1 NovemberPages –, Lipid peroxidation and glutathione peroxidase in ischemic heart disease Article in Indian Journal of Clinical Biochemistry 16(2) July with 28 Reads How we measure 'reads' Plasma, platelet and erythrocyte glutathione peroxidases as risk factors in ischaemic heart disease in man.

Population risk of cardiovascular disease: the Minnesota Heart Survey. Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and ://   Cmangdong Medical Col— lege,Zha巧iang ,China tgey words]Plasma glutathione peroxidase; Cerebrovascular disease Heart ’在该基因的启动子区和3’非翻译区有多个 CACC/GT基序、EST样结合位点及1个GAT型蛋 白结合位点。 › 百度文库 › 行业资料.

Vitamin E comsumption and the risk of coronary disease in women. New Engl J Med[37] Steinberg D. Antioxidants in the prevention of human atherosclerosis. Circulation[38] Jansson J-H, Nilsson TK, Johnson 0. von Willebrand factor in plasma: a novel risk factor for recurrent myocar- dial ://   Key Points.

Elevated plasma levels of homocysteine are associated with atherosclerosis and cardiovascular ischemic events. Hyperhomocysteinemia (HHcy) is an independent risk factor for ischemic heart disease, stroke, hypertension, arrhythmia, and peripheral vascular ://   The burden of ischaemic heart disease (IHD) continues to grow in the developed world with a greater fraction of the population composed of older people.

In the USA, heart disease is the leading cause of death overall and in those over 65 years of age.1 The most accepted theory for the cause of IHD remains high total or elevated LDL cholesterol, which in turn is due to a high intake of dietary The glutathione peroxidase 3 gene (GPX3) is reported to be a risk factor for arterial ischaemic stroke and cerebral venous thrombosis.

GPX3 may be one of the aetiologies of sudden sensorineural Stroke is a leading cause of morbidity and mortality worldwide. Oxidative stress which is as a result of increased activity of free radicals and decreased antioxidant mechanism plays a major role in the pathogenesis of stroke.

This study determined the plasma level of malondialdehyde (MDA), a marker of lipid peroxidation and oxidative stress and enzymatic Antioxidants namely, superoxide   Cardiovascular disease is the leading cause of death worldwide [].Hyperlipidemia is a major risk factor for coronary artery disease (CAD).

A higher level of low density lipoprotein-cholesterol (LDL-C) can increase the incidence of CAD [].The 3-hydroxymethylglutaryl coenzyme A reductase (HMG-Co A reductase) inhibitors (statins) have been the most popular drugs for reducing the level of LDL-C The immune system and detoxification system cannot function without GSH.

In his book " body's most powerful protector" Dr. Jimmy Gutman says "Glutathione modulation is an essential part of staying young, active and healthy." He also states - "By keeping our intracellular GSH levels up we also keep our immune system on the ball and fully armed" Voetsch B, Jin RC, Bierl C, Benke KS, Kenet G, Simioni P, Ottaviano F, Damasceno BP, Annichino-Bizacchi JM, Handy DE, Loscalzo J.

Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and ://   Promoter polymorphisms in the plasma glutathione peroxidase (GPx-3) gene: a novel risk factor for arterial ischemic stroke among young adults and children.

Stroke ; 41– CAS Diabetes mellitus, a major risk factor for the development of heart disease in humans, is associated with a phase shift in the cardiac circadian clock [14, 15]. Shift workers have an increased incidence of cardiovascular disease [], which might be related to alterations in cardiovascular intracellular circadian clock ://   In a large prospective study in Denmark, an increased risk of ischaemic heart disease (relative risk ) was observed among subjects with serum Extensive evidence has demonstrated that many antioxidants such as vitamin C, vitamin E, carotenoids and polyphenols have protective effects in preventing cardiovascular disease (CVD), a chronic disease that is mediated by oxidative stress and inflammation.

This review focuses on evidence from prospective cohort studies and clinical trials in regard to the associations between plasma/dietary   Free radical production occurs continuously in all cells as part of normal cellular function.

However, excess free radical production originating from endogenous or exogenous sources might play a role in many diseases. Antioxidants prevent free radical induced tissue damage by preventing the formation of radicals, scavenging them, or by promoting their :// 1 day ago  Objectives High levels of plasma homocysteine have been reported to be toxic to the vascular endothelium, thereby creating an environment of hypercoagulability and occlusion.

Elevated homocysteine has been reported as a risk factor for young adult central retinal vein occlusion (CRVO) cases. This study aimed to see if oxidative stress is an independent risk factor or is homocysteine J Clin Hypertens (Greenwich).

;– © Wiley Periodicals, Inc. Mercury has a high affinity for sulfhydryl groups, inactivating numerous enzymatic reactions, amino acids, and sulfur‐con   J Thambyrajah, J.N Townend; Homocysteine and atherothrombosis—mechanisms for injury, European Heart Journal, Vol Is 1 JunePages –, h The essential trace mineral, selenium, is of fundamental importance to human health.

As a constituent of selenoproteins, selenium has structural and enzymic roles, in the latter context being best-known as an antioxidant and catalyst for the production of active thyroid hormone.

Selenium is needed for the proper functioning of the immune system, and appears to be a key nutrient in   Plasma Glutathione Peroxidase Assay. Plasma from subjects was analyzed for plasma glutathione peroxidase using an ELISA kit (OXIS Internatl., Portland, OR).

Two replicates per sample of 20 μl of plasma were diluted with TRIS-HCl buffer then pippetted into pre-coated polyclonal antibodies microplate wells specific for human plasma Fuller JH, Pinney S, Jarrett RJ, Kilbourn K, Keen H.

Plasma lipids in a London population and their relation to other risk factors for coronary heart disease. Br Heart J. Feb; 40 (2)– [PMC free article] Bainton D, Burns-Cox CJ, Elwood PC, Lewis B, Miller NE, Morgan K, Sweetnam PM.

Prevalence of ischaemic heart disease and Selenium is incorporated into selenoproteins that have a wide range of pleiotropic effects, ranging from antioxidant and anti-inflammatory effects to the production of active thyroid hormone.

In the past 10 years, the discovery of disease-associated polymorphisms in selenoprotein genes has drawn attention to the relevance of selenoproteins to ://(11)/fulltext. Newer aspects of micronutrients in chronic disease: copper BY J. STRAIN Human Nutrition Research Group, mechanisms involved in ischaemic heart disease (IHD), the chronic disease which is the Cu, also, has been identified as a risk factor for IHD in a Finnish prospective study (Salonen et al.

The latter workers have concluded. BACKGROUND/AIMS Hyperhomocyst(e)inaemia has been identified as a strong risk factor for stroke, myocardial infarction, and deep vein thrombosis. A point mutation of methylene tetrahydrofolate reductase (MTHFR CT) has been associated with increased plasma homocyst(e)ine levels.

To investigate whether hyperhomocyst(e)inaemia and/or MTHFR CT mutation are Oxidative stress caused by an excess of reactive oxygen species (ROS) is known to contribute to stroke injury, particularly during reperfusion, and antioxidants targeting this process have resulted in improved outcomes experimentally.

Unfortunately these improvements have not been successfully translated to the clinical setting. Targeting the source of oxidative stress may provide a superior Patients with type II Diabetes Mellitus (NIDDM) are more prone to Ischaemic Heart Disease (IHD).

Although, oxygen free radicals are known to contribute to the development of IHD, conflicting reports are available regarding the antioxidant status in patients of NIDDM complicated with